VERY frustrating problem...Can't log in and gives me an error which doesn't tell me anything...

This is SugarCRM Enterprise, Version 7.6.2.2 (Build 45)

So this instance all of a sudden won't let anyone log in.  Here is the VERY non-descript/unhelpful error message:

Unable to sync with server.  A request is failing that makes the application unusable.  Please contact technical support.

It runs on Linux (CentOS 6.x) and the database is MySQL, and I have full access to a Linux terminal.  I've restarted MySQL and Apache and the problem continues to persist.

Is there something useful being logged somewhere, and where should I look?

Thanks!