Error 500 after update centos 6

Good Mooring. Please help me in this error.

After update the Centos packages (Yum update) When i receive the  error 500in the sugar crm login Page

I check the file permisions, and php, and everything looks fine. I search in google for this error but i didn't find a valid solution.

PHP version: 5.3.3.

CentOS 6.8.

The SQL database is running fine.

The sugarcrm.log doesn't show information about the error.

Thanks

David